Hi there tstruna,
I have a 2007 EX-L 2 wheel drive with 121,000 miles and I get 27 to 28 mpg on the highway. When I filled up yesterday the range had 411 mpg but that is because of highway driving. I drive once a week out of town approximately 200 miles on the highway. I also use cruise control on the highway and stay at a steady clip. And I do not accelerate, I gently move about. I use regular gasoline and have all current maintenance up to date. I get about 19 to 20 mpg in the city. One of the things I am doing is changing my oil at 3,000 miles because my many years mechanic and vehicle wise part mechanic part engineer brother recommended it. So, I am not going by maintenance minder for the oil change.
Also, living in Texas it is also recommended that the oil be changed because of the intense heat.